HEPATOCURATIVE AND ANTIOXIDANT EFFECT OF ETHYL-ACETATE AND N-BUTANOL FRACTIONS OF Detarium microcarpum STEM BARK IN CCl4 INDUCED LIVER DAMAGE IN WISTAR RATS

3,000.00

Category:
RESEARCH INFORMATION

✎: HEPATOCURATIVE AND ANTIOXIDANT EFFECT OF ETHYL-ACETATE AND N-BUTANOL FRACTIONS OF Detarium microcarpum STEM BARK IN CCl4 INDUCED LIVER DAMAGE IN WISTAR RATS

❐: Chapter 1 – 5
♣:₦3, 000
❑: Ms Word format

: GET COMPLETE PROJECT MATERIAL

This study, “HEPATOCURATIVE AND ANTIOXIDANT EFFECT OF ETHYL-ACETATE AND N-BUTANOL FRACTIONS OF Detarium microcarpum STEM BARK IN CCl4 INDUCED LIVER DAMAGE IN WISTAR RATS” contains concise information that will serve as a framework or guide for your project work. The project study is well-researched for academic purposes and are usually provided in complete chapters with adequate References.

Keywords: HEPATOCURATIVE AND ANTIOXIDANT EFFECT OF ETHYL-ACETATE AND N-BUTANOL FRACTIONS OF Detarium microcarpum STEM BARK IN CCl4 INDUCED LIVER DAMAGE IN WISTAR RATS

 

RESEARCH BODY

TABLE OF CONTENTS

CHAPTER ONE

1.0       INTRODUCTION

1.1       Preamble

1.2       Statement of Research Problem

1.3       Justification

1.4       Aim and Objectives

1.4.1    Aim

1.4.2    Specific objectives

1.5       Null Hypothesis

CHAPTER TWO

2.0       LITERATURE REVIEW

2.1       Detarium microcarpum. Guill and Perr

2.1.1    Classification of the plant

2.1.2    Description, distribution and habitat of Detarium microcarpum

2.1.3    General uses of Detarium microcarpum plant

2.1.4    Ethno-medicinal uses

2.2 Phytochemical profile of Detarium microcarpum plant

2.3 Pharmacological activities

2.3.1    Antidiabetic activity

2.3.2    Antibacterial and antifungal activities

2.3.3    Antiviral activity

2.3.4    Enzyme inhibition

2.3.5    Antisnake venom activity

2.4.      The Liver

2.4.1    Structure and functions

2.4.2    Liver cells

2.4.3    Xenobiotics and liver metabolism

2.4.4    Mechanisms of hepatic injury

2.5       Mode of action of liver toxicants

2.5.1    Carbon tetrachloride (CCl4) induced hepatotoxicity

2.6       Liver injuries

2.6.1    Cholestatic liver injury

2.6.2    Fatty liver (Steatosis)

2.6.3    Cell death

2.7       Biochemical alterations in hepatic damage

2.7.1    Serum aminotransferase enzymes

2.7.2    Serum alkaline phosphatase

2.7.3    Serum total protein and albumin

2.7.4    Serum bilirubin

2.8       Silymarin

CHAPTER THREE

3.0       MATERIALS AND METHODS

3.1       Materials

3.1.1    Chemicals/reagents

3.1.2    Plant sample collection and identification

3.1.3 Experimental animals

3.2 Methodology

3.2.1    Preparation of plant sample

3.2.2    Aqueous extract preparation

3.2.3    Fractionation

3.2.4    Qualititative phytochemical analysis

3.2.5    Quantitative phytochemical analysis

3.2.6    In-vitro antioxidant activity

3.2.7    Acute toxicity studies

3.2.8    Induction of liver damage

3.2.9    Experimental design

3.2.10  Biochemical analysis

3.2.11  Determination of oxidative stress parameters

3.3 Statistical Analysis

CHAPTER FOUR

4.0       RESULT

4.1       Qualitative Screening of Phytochemicals

4.2       Total flavonoid / total phenolic content

4.3       In-vitro Antioxidant Activity

4.3.1    DPPH radical scavenging activity

4.3.2    Reducing power assay

4.3.3    Hydrogen peroxide (H202) radical scavenging activity

4.4       Lethal Dose Determination

4.5       Effect of n-butanol fraction on body weight / organ weight

4.4.1    Effect of n-butanol fraction on body weight

4.4.2    Effect of n-butanol fraction on relative organ weight

4.5       Biochemical Parameters

4.5.1    Effect of n-butanol fraction on serum liver damage biomarkers/liver function parameters in CCl4 induced liver damage in rats

4.5.2    Effect of n-butanol fraction on kidney function parameters of CCl4 induced liver damage in rats

4.6       Oxidative Stress Parameters

4.6.1    Effect of n-butanol fraction on oxidative stress parameters in CCl4 induced liver damage in rats

CHAPTER FIVE

5.0 DISCUSSION

CHAPTER SIX

6.0       Summary, Conclusion and Recommendations

6.1       SUMMARY

6.2       CONCLUSION

6.3       RECOMMENDATIONS

REFERENCE

 

Keywords: HEPATOCURATIVE AND ANTIOXIDANT EFFECT OF ETHYL-ACETATE AND N-BUTANOL FRACTIONS OF Detarium microcarpum STEM BARK IN CCl4 INDUCED LIVER DAMAGE IN WISTAR RATS

 


DO YOU WANT TO ORDER FOR THE COMPLETE PROJECT MATERIAL? Then click here

GET COMPLETE PROJECT

Have you made payment for this project? If YES, contact our Customer Care.

For further enquiries, call our Hotlines ☎: 08139342394 or 08152487601


PROJECT TOPICS AND MATERIALS | HIRE A WRITER | HOW TO PAY FOR PROJECT

 

Keywords: HEPATOCURATIVE AND ANTIOXIDANT EFFECT OF ETHYL-ACETATE AND N-BUTANOL FRACTIONS OF Detarium microcarpum STEM BARK IN CCl4 INDUCED LIVER DAMAGE IN WISTAR RATS

DISCLAIMER: hiWriters.com.ng focus on attracting students and researchers to materials that can be used as guide, framework, and reference for their project work. All contents/materials on this website are for research purposes only and for no reason should you copy verbatim. This platform is not encouraging any form of plagiarism, neither are we advocating the use of the project materials for cheating. We strictly recommend that research project topics and materials ordered for should serve as a guide or framework only. The contents therein should be used to generate fresh ideas for your own research. Finally, hiWriters.com.ng will not be liable for any material used inappropriately.