THE EFFECT OF ETHANOLIC EXTRACT OF ACANHUS MONTANUS ON FASTING BLOOD SUGAR LEVELS OF ADULT WISTAR RATS

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✎: THE EFFECT OF ETHANOLIC EXTRACT OF ACANHUS MONTANUS ON FASTING BLOOD SUGAR LEVELS OF ADULT WISTAR RATS

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Keywords: THE EFFECT OF ETHANOLIC EXTRACT OF ACANHUS MONTANUS ON FASTING BLOOD SUGAR LEVELS OF ADULT WISTAR RATS

 

RESEARCH BODY

ABSTRACT

This research work was carried out to determine the effect of Acanthus montanus on fasting blood sugar level of adult wistar rats. Twenty wistar rats (both male and female) weighing between 140g to 160g were used for this research project. They were acclimatized for 14 days after which the animals were grouped into four groups of five rats each. Each animal were administered based on their body weight. The dose given to animals in group A was 300mg/kg body weight of Acanthus montanus, Group B was given 500mg/kg body weight of Acanthus montanus, Group C was given 700mg/kg body weight of Acanthus montanus and group D (control group) was given distilled water. The administration lasted for thirteen days. A day before the animals were tested for fasting blood sugar level, food and water was withdrawn and they fasted for twelve hours. Blood samples were collected from the tail of the animals and the fasting blood sugar of each of the animals was tested.

      CHAPTER ONE

1.0            INTRODUCTION

1.1     PLANTS

Plants are living things that usually have root, stem, leaves to produce fruits and seeds. Plants naturally grow on the surface of the earth (Akpanabiatu et al., 2005). Human being has faced series of challenges in preventing and eliminating diseases in the body. The discovery of the efficacy of certain plant species in herbal remedies by man may have come as a result of trial and error (Hostettmann et al., 2000). This however, has created some gap in common believe on the treatment of ailments among some related and unrelated human societies of the world. The importance of medicinal plants as well as their roles in nature cannot be over emphasized (Shirwakar et al., 2006).  Most plants are edible and contain different amount of vitamins, protein or carbohydrates etc., these helps the body to replace worn out cells or tissues, digest food and combat ailments among other health related problems. Phytochemical analysis on certain plant species by some modern practitioners have shown some corresponding results with already existing tradomedical information while in some cases have differed completely thereby causing doubt in herbal treatment.  Since the dawn of history, man has been faced with the challenges of eliminating ailments completely, which inheritance has not been met, therefore different ages have been adopting different measures to help check ailments but from creation to date, plants have always been among the most effective primary measures for this check (Porter, 1997).

Series of medicinal plants are continually being utilized for therapeutic purposes in treating diseases in the traditional ethno-medicinal system. Plants have a core ability to combat ailment and maintain one’s state of good health, since it provides the body with vital nutrients (Coskum et al., 2005). Scientifically, plants have been proven to have the ability to cure ailments by providing some necessary nutrients which may be lacking in the body or by attacking the causative organisms themselves. On the other hand, different plant species perform varied roles (ecological niche) which has been harnessed by the ancient and correspondingly used to combat human pathology. Man has used plants from the earliest times to cure disease and relieve physical suffering (Mbagwu, 2009). Medicinal value of drug plant is due to the presence of some chemical substances (active ingredients) that produce a definite physiological action in the human body (Mbagwu, 2009).

The importance of plants in medicine remains even of greater relevance with the current global shift to obtain drugs from plant sources, as a result of which attention has been given to the medicinal value of herbal remedies for safety, efficacy and economy (Mahabir and Gulliford, 1997). The World Health Organization in a number of resolutions emphasized the need to ensure the quality control of plant products by using modern techniques and applying suitable standards (WHO, 1992).

The World Health Organization (WHO) defines traditional medicine as practices, knowledge and belief systems which use minerals, plants and animal based remedies, spiritual therapies and exercises to prevent, treat and maintain wellbeing (WHO, 1978). Meanwhile, Muthuet al. (2006) stated that about 80% of the population of the world depends on traditional medicine, mostly herbal remedies, for their primary health care needs.

 

Keywords: THE EFFECT OF ETHANOLIC EXTRACT OF ACANHUS MONTANUS ON FASTING BLOOD SUGAR LEVELS OF ADULT WISTAR RATS

 


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Keywords: THE EFFECT OF ETHANOLIC EXTRACT OF ACANHUS MONTANUS ON FASTING BLOOD SUGAR LEVELS OF ADULT WISTAR RATS

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